Dermatological Findings in Glaucoma Patients: Comparison Between Pseudoexfoliative and Primary Open-angle Glaucoma

Purpose: To compare the frequency of dermatological manifestations between patients with pseudoexfoliative glaucoma and those with primary open-angle glaucoma. Methods: A cross-sectional study was done on all consecutive pseudoexfoliative glaucoma (PEXG) and primary open-angle glaucoma (POAG) patients evaluated in a tertiary eye hospital during the study period. Eligible patients were referred to the dermatology department for complete skin, hair, nail, and mucosal examinations. Results: Twenty-one patients in the PEXG group and 26 patients in the POAG group were included in this study. The most common skin manifestations in the study were seborrheic dermatitis, dry skin, and cherry angioma. The frequency of lentigines was significantly higher in the PEXG patients than in the POAG group (P = 0.013). More than half of the study population had seborrheic dermatitis (57.1% and 61.5% in the PEXG and POAG groups, respectively); however, the difference between the groups was not statistically significant (P = 0.775). Similarly, the frequencies of skin dryness, cherry angioma, nevus, psoriasis, contact dermatitis, itching, seborrheic keratoses, notalgia paresthetica, and vitiligo in the two groups were not statistically significantly different (P > 0.1 for all comparisons). There was no significant association between the frequency of the investigated skin manifestations and patients’ age, visual acuity, intraocular pressure, and cup-to-disc ratio. Conclusion: Integumentary system disorders are pervasive in glaucoma patients, and dermatologic evaluation in glaucoma patients should be considered for diagnostic and therapeutic purposes

Macular Amyloidosis and Epstein-Barr Virus

Background. Amyloidosis is extracellular precipitation of eosinophilic hyaline material of self-origin with special staining features and fibrillar ultrastructure. Macular amyloidosis is limited to the skin, and several factors have been proposed for its pathogenesis. Detection of Epstein-Barr virus (EBV) DNA in this lesion suggests that this virus can play a role in pathogenesis of this disease. Objective. EBV DNA detection was done on 30 skin samples with a diagnosis of macular amyloidosis and 31 healthy skin samples in the margin of removed melanocytic nevi by using PCR. Results. In patients positive for beta-globin gene in PCR, BLLF1 gene of EBV virus was positive in 23 patients (8 patients in case and 15 patients in the control group). There was no significant difference in presence of EBV DNA between macular amyloidosis (3.8%) and control (23.8%) groups (P=0.08). Conclusion. The findings of this study showed that EBV is not involved in pathogenesis of macular amyloidosis

A National Survey: Desire of Dermatology Residents to Train in Cosmetic Dermatology and Its Association With Learning Medical Dermatology

The main challenge for training in cosmetic dermatology is the difference in the attitudes of residency programs and residents about the necessity and amount of education during the residency period. A national online survey conducted between September 6th and November 21st, 2017. Residents, members of the Iranian Board of Dermatology, faculty members and program directors (PDs) were asked to participate in the survey.174 participants from 12 residency programs participated in this study and the response rate of residents, professors, and Dermatology Board Directory Members (Boardmans) and PDs was 89.8%, 61.7%, and 81.8%, respectively. Residents declared greater tendency towards practicing medical dermatology (mean score, 5.165±0.8335) over the five years after graduation than that of was perceived by professors (4.043±1.2988), and Boardmans and PDs (4.059±1.0290) (P˂0.001). The first residents’ priority was practicing in medical dermatology (5.165±0.8335) during 5-years after graduation. However, professors (5.261±0.8282) and Boardmans and PDs (5.176±0.7276) predicted residents' first priority would be practicing cosmetic dermatology (P˂0.001). Forty one (60.3%) of the professors, Boardmans, and PDs agreed or strongly agreed that residents’ desire to learn more about cosmetic procedures resulted in their decreased interest in learning medical procedures (P=0.18). Medical dermatology is still clearly the basis for training in residency programs,and even for residents who have a high tendency to practice cosmetic dermatology, there is a strong tendency to work in the field of medical dermatology as well

Epidemiology of pemphigus in northeast Iran: A 10-year retrospective study

Pemphigus is an autoimmune blistering disease of the skin and mucous membranes with different reported epidemiological aspects from different countries. <b> Aim:</b> Our aim was to evaluate the epidemiological aspects of pemphigus in Mashhad city. This is the first report with regard to the characteristics of pemphigus in Khorasan province of Iran. <b> Materials and Methods:</b> In this cross-sectional study, all the patients with pemphigus, who were referred to the Dermatology Department of Imam Reza hospital of Mashhad, were examined over nine years, i.e., from May 1998 to March 2007. The data obtained through questionnaires, including age, sex, profession, mucosal or skin or the involvement of both, lag-time period between the onset of disease and the first presentation, gap between cutaneous and mucosal involvements, season of onset and family history, were analysed by using statistical tests of Chi square and Student&#x2032;s <i> t</i> -test and the statistical software of SPSS. <b> Results:</b> In 178 patients with pemphigus, pemphigus vulgaris was the most common type (86.5&#x0025;). Female to male ratio was 1.4. In pemphigus vulgaris patients, there was involvement of both the skin and mucosa in 64.3&#x0025;, mucosal involvement in 14&#x0025; and skin involvement in 21.7&#x0025;. There was no mucosal involvement in patients with pemphigus foliaceus. Two patients (1.4&#x0025;) had a positive family history. Summer was the most common season for the onset of the disease (37.5&#x0025;). Most of the patients were housewives in the premenopausal age group. <b> Conclusion:</b> The results reveal a high incidence of pemphigus in northeast Iran with an incidence of 20 patients per year

پروفایل سرشت های عاطفی به عنوان یک عامل زمینه ساز برای پسوریازیس پلاک مزمن

مقدمه: اگرچه رابطه نزدیکی بین پسوریازیس و مسائل روانی از جمله سرشت عاطفی وجود دارد، اما مطالعات کمی به این ارتباط پرداخته اند. این مطالعه با هدف بررسی پروفایل سرشت عاطفی در بیماران مبتلا به پسوریازیس پلاکی مزمن انجام شد.روش‌ کار: این مطالعه مقطعی در سال 98-1397 در کلینیک سرپایی پوست بیمارستان امام رضا (ع) مشهد انجام شد. در مطالعه حاضر، 40 بیمار پسوریازیس و 40 داوطلب سالم همسان از نظر جنس و سن شرکت کردند. ابزارهای تحقیق شامل پرسشنامه  ممفیس، پیزا، پاریس و سن دیگو  (TEMPS-A)، پرسشنامه اضطراب بک (BAI) و پرسشنامه افسردگی بک II (BDI-II)  بود. برای مقایسه متغیرهای اسمی و طبقه‌ای از آزمون‌های تی، من-ویتنی و مجذور خی استفاده شد. برای ارزیابی همبستگی ها از آزمون های اسپیرمن و پیرسون استفاده شد.یافته‌ها: در مجموع، 36 نفر از 80 بیمار (45%) مرد بودند. خلق و خوی افسرده، سیکلوتایمیک و مضطرب در گروه پسوریازیس به طور معنی‌داری برجسته‌تر بود (001/0 P<)، در حالی که نمره هیپرتایمیک در گروه شاهد به‌طور قابل‌توجهی بالاتر بود (023/0=P). بین شدت بیماری (نمره PASI) و سرشت عاطفی مختلف ارتباط معنی داری وجود نداشت. مدت درگیری پسوریازیس با تمام سرشت های عاطفی همبستگی منفی متوسطی داشت (05/0 P<) به جز سرشت هیپرتایمیک. شیوع اضطراب (80 درصد در مقابل 30 درصد، 40=n؛ 001/0 P<) و افسردگی (60 درصد در مقابل 5/32 درصد، 40=n؛ 009/0= P) در بیماران پسوریازیس به طور معنی‌داری بیشتر از گروه شاهد بود.نتیجه گیری: به نظر می رسد سرشت سیکلوتایمیک، افسرده و مضطرب و همچنین اضطراب و افسردگی در بیماران پسوریازیس به طور قابل توجهی شیوع بیشتری داشته باشد. با این حال، این ها با شدت بیماری همبستگی نداشتند

Serum lipids abnormalities and psoriasis

Context: Psoriasis is a chronic proliferative inflammatory skin disease with unknown etiology. The loss of scale from the surface observed in the course of psoriasis may be related to lipid disorders in epidermis and in serum. Moreover a predisposition to occlusive vascular disease and increased cardiovascular morbidity has been reported. Aims: In this study, the serum lipid levels of psoriatic patients were investigated to detect any relation in this respect. Materials and Methods: 60 psoriatic and 120 nonpsoriatic individuals were included in this case control study and were analogized for sex, age and body mass indices. Total cholesterol, triglyceride, high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) levels were measured. Statistical Analysis Used: Collected data were analyzed by statistical tests of Chi square, Mann Whitney and Kruskal Wallis applying SPSS software. Results: Total cholesterol, triglyceride and LDL-C were found to be significantly higher than in normal control group ( P &#60; 0.05). No significant statistical difference was observed between HDL level of the two groups. Conclusions: We concluded that psoriatic patients should be evaluated for hyperlipidemia and obstructive vascular diseases. Administrating lipid-lowering medicines for patients particularly cases with severe disease may be beneficial prognosis

Clinicopathological evaluation of radiation induced basal cell carcinoma

Background: Development of skin neoplasms is one of the most important chronic complications of radiation therapy. Basal cell carcinoma (BCC) is the most frequent carcinoma occurring at the region of the body to which radiotherapy was delivered. Aim: The aim of this study was to evaluate clinical and histological aspects of basal cell carcinoma in patients with a history of radiotherapy. Materials and Methods: Medical records and microscopic slides of 80 patients with basal cell carcinoma who had received radiotherapy (1996-2006) were reviewed in pathology department of Imam Reza hospital of Mashhad, Iran. Collected data were analyzed statistically using descriptive test. Results: 60 men and 20 women were included, majority of them in their sixties. Plaque was the most common clinical pattern of basal cell carcinoma. Fifty one percent of the patients had pigmented and 42.5&#x0025; had multiple lesions. Scalp was the most common site of involvement. Histologically, macronodular and pigmented carcinoma were the most predominant forms of basal cell carcinoma. Discussion: Majority of patients had scalp involvement and multiple lesions. Nodular and pigmented forms were the most common histological findings. We suggest the need for close supervision in patients with a history of radio therapy in the past